news
December 2022
Our work describing LUBAC and linear ubiquitination as a novel regulator of necroptosis by controlling the membrane accumulation of activated MLKL in primary human pancreas organoids is now online at bioRxiv! Find the full text here!!!
August 2022
Very happy that our work in which we have identified USP22 as negative regulator of interferon signaling, ISG expression and important host factor against SARS-CoV-2 infection, is now online! Find the full text here!!!
July 2022
Successfully habilitatated at the Medical Faculty of the Goethe University!!! Thanks a lot to all past and current labmembers, colleagues, collaborators and supervisors!!!
November 2021
The latest review describing the role of RIPK3 and MLKL ubiquitination for necroptotic cell death is now online!!! See here!!!
September 2021
Our new institutional website is online (at the moment only in German, Englisch translation will follow soon…)!!!
April 2021
Jens succesfully defended his PhD!!! Congratulations and many thanks for all the great work!!!
December 2020
The article in which we describe our discovery that USP22 controls necroptotic cell death by regulating RIPK3 ubiquitination is now published in EMBO Reports!!! Read the full text HERE!
December 2020
Our review about the contribution of specific cell organelles in autophagy-dependent cell death by Laura Zein is published in Matrix Biology!!! The full text of the the paper can be accessed HERE!!!
December 2020
Our article about ATM, Auranofin and cell death is by Vanessa Ehrenfeld and Jan Heusel is published in PLOS One! The full text of the the paper can be accessed HERE!!!
December 2020
The review about the many interesting functions of the linear ubiquitin-specific deubiquitinating enzyme OTULIN in cell fate and beyond by Nadine Weinelt and myself, is now online in Cell Death & Differentiation. The full text of the the paper can be accessed HERE!!!
October/November 2020
The paper by Svenja, Simon and Laura is finally online!!! We describe a fascinating connection between drug-induced autophagy-dependent cell death, ER stress and ER-specific autophagy in glioblastoma cells!!! The full text of the the paper can be accessed HERE!!!
October 2020
Very happy to have Henri Schamburg for an internship and Clara Goebel for a Deutsche Krebshilfe-funded MD in our lab!!! Welcome!!!
August 2020
Svenja Zielke successfully defended her PhD on August 31st!!! Svenja worked on studying autophagy-related cell death in glioblastoma and published some very nice papers… Congratulations!!!
Juli 2020
Our collaborative study in which we unravel the mechanisms of drug-induced ER-phagy in glioblastoma has been accepted by Autophagy!!! More info soon…
May 2020
Our manuscript, in which we use quantitative, single-molecule TNFR1-mEos2 PALM imaging to evaluate TNFR1 antagonists (such as the CysLTR1 antagonist zafirlukast), is now accepted for publication by the Journal of Leukocyte Biology!!! In collaboration with the labs of Mike Heilemann (Frankfurt) and Harald Wajant (Würzburg), Nadine Weinelt and Christos Karathanasis demonstrated that our single-molecule TNFR1-mEos2 imaging system can be used to test, characterize and evaluate chemical inhibitors that interfere with TNFR1 clustering and activation of downstream NF-kB activation!
