L. Zein#, M. Dietrich#, D. Balta, V. Bader, C. Scheuer, S. Zellner, N. Weinelt, J. Vandrey, M. C. Mari, C. Behrends, F. Zunke, K. F. Winklhofer, S. J. L. van Wijk (2024). Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival. Full text access on bioRxiv HERE.

36. L. Kowald, J. Roedig, R. Karlowitz, K. Wagner, S. Smith, T. Juretschke, P. Beli, S. Müller, S. J. L. van Wijk (2024) USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression. Accepted for publication in Cell Death Disc.

35. N. Weinelt, K. N. Wächtershäuser, S. Smith, G. Andrieux, T. Das, B. Jeiler, J. Roedig, L. Feist, B. Rotter, M. Boerries, F. Pampaloni, S. J. L. van Wijk (2024) Species-specific LUBAC-mediated M1 ubiquitination regulates necroptosis by segregating the cellular distribution and fate of activated MLKL. Cell Death Dis. Full text access HERE

34. L. Reisbeck, B. Linder, G. Tascher, S. Bozkurt, K. Weber, C. Herold-Mende, S. J. L. van Wijk, R. Marschalek, L. Schaefer, C. Münch, D. Kögel (2023) The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells, AJP: Cell Physiology. Full text access HERE

33. R. Karlowitz, M.L. Stanifer, J. Roedig, G. Andrieux, D. Bojkova, M. Bechtel, S. Smith, L. Kowald, R. Schubert, M. Boerries, J. Cinatl Jr., S. Boulant, S. J. L. van Wijk (2022) USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING, Cell Death Dis. Full text access HERE 

32. C. Wolf, S. Smith, S. J. L. van Wijk (2022) Zafirlukast induces VHL- and HIF-dependent oxidative cell death in clear cell renal carcinoma cells, Int. J. Mol. Life Sci. Full text access HERE 

31. R. Karlowitz, S. J. L. van Wijk (2022) Surviving death: emerging concepts of RIPK3 and MLKL ubiquitination in the regulation of necroptosis, FEBS J. Full text access HERE 

30. S. Hannes*, R. Karlowitz*, S. J. L. van Wijk (2021) The Smac mimetic BV6 cooperates with STING to induce necroptosis in apoptosis-resistant pancreatic carcinoma cells, Cell Death Dis. Full text access HERE * shared first authorship

29. A. Koch, B. Jeiler, J. Roedig, S. J. L. van Wijk, N. Dolgikh, S. Fulda (2021) Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt’s lymphoma cell lines, Neoplasia. Full text access HERE

28. D. J. Klionsky, … S. J. L. van Wijk, …., C.-K. Tong (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition), Autophagy. Full text access HERE

27. J. Roedig, L. Kowald, T. Juretschke, R. Karlowitz, B. Ahangarian Abhari, H. Roedig, S. Fulda, P. Beli, S. J. L. van Wijk (2020) USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination, EMBO Reports. Full text access HERE

26. L. Zein, S. Fulda, D. Kögel, S. J. L. van Wijk (2020) Organelle-specific mechanisms of drug-induced autophagy-dependent cell death, Matrix Biology. Full text access HERE

25. V. Ehrenfeld*, J. Heusel*, S. Fulda, S. J. L. van Wijk (2020) ATM inhibition enhances Auranofin-induced oxidative stress and cell death in lung cell lines, PLOS One. Full text access HERE * shared first authorship

24. N. Weinelt, S.J.L. van Wijk (2020) Ubiquitin-dependent and -independent functions of OTULIN in cell fate control and beyond, Cell Death & Differentiation. Full text access HERE

23. S. Zielke*, S. Kardo*, L. Zein*, M. Mari, A. Covarrubias, M. N. Kinzler, N. Meyer, A. Stolz, S. Fulda, F. Reggiori, D. Kögel, S.J.L. van Wijk (2020) ATF4 links ER stress with ER-phagy in glioblastoma cells, Autophagy. Full text access HERE * shared first authorship

22. N. Weinelt, C. Karathanasis, S. Smith, J. Medler, S. Malkusch, S. Fulda, H. Wajant, M. Heilemann, S. J. L. van Wijk (2020) Quantitative single-molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα-induced NF-ĸB signaling, Journal of Leucocyte Biology, doi: 10.1002/JLB.2AB0420-572RR.

21. A. Dietz, N. Dalda, S. Zielke, J. Dittmann, S. J. L. van Wijk, M. Vogler, S. Fulda (2020) Proteasome inhibitors and Smac mimetics cooperate to induce cell death in Diffuse Large B-cell Lymphoma by stabilizing NOXA and triggering mitochondrial apoptosis, International Journal of Cancer, 147 (5): 1485-1498

20. M. N. Kinzler, S. Zielke, N. Meyer, D. Kögel, S. J. L. van Wijk*, Simone Fulda* (2020) STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts, Scientific Reports, 10 (1): 687. * shared senior authorship

19. C. Karathanasis, J. Medler, F. Fricke, S. Smith, S. Malkusch, D. Widera, S. Fulda, H. Wajant, S. J. L. van Wijk*, I. Dikic*, M. Heilemann* (2020) Single-molecule imaging reveals the oligomeric state of functional TNF-induced plasma membrane TNFR1 clusters in cells, Science Signaling, 13(614). * shared senior authorship

18. S. J. L. van Wijk*, S. Fulda, I. Dikic, M. Heilemann* (2019) Visualizing ubiquitination in mammalian cells, EMBO Reports, eb; 20(2). pii: e46520. * shared senior authorship

17. M. Smith, A. Dietz, K. Henz, R. Jackson, L. Kowald, S. J. L. van Wijk, S. Jayne, S. Macip, S. Fulda, M. J. S. Dyer, M. Vogler (2019) BCL-2, BCL-XL, or MCL-1 maintain survival of Diffuse Large B-cell Lymphoma cells by sequestering and inhibiting BAX, Haematologica, Oct 10. pii: haematol.2019.220525.

16. T. Frank, M. Tuppi, M. Hugle, V. Dötsch, S.J.L. van Wijk*, S. Fulda* (2019) Cell cycle arrest in mitosis promotes interferon-induced necroptosis, Cell Death and Differentiation, Oct;26 (10):2046-2060. * shared senior authorship

15. N. Schmidt, S. J. L. van Wijk, S. Fulda (2019) Smac mimetic BV6 induces divergent activation of canonical and non-canonical NF-ĸB signaling in breast cancer cell lines, Biological Chemistry, Jan 28;400(2):171-180.

14. A. Knuth, S. Rösler, B. Schenk, L. Kowald, S. J. L. van Wijk, S. Fulda (2018) Interferons transcriptionally upregulate MLKL expression in cancer cells, Neoplasia, Jan; 21(1): 74-81.

13. Zielke, N. Meyer, M. Mari, F. Reggiori, S. J. L. van Wijk*, D. Kögel*, S. Fulda* (2018) Loperamide, pimozide and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells, Cell Death and Disease, Sep 24;9(10):994. * shared senior authorship

12. Hussain, V. Zimmermann, S. J. L. van Wijk*, S. Fulda* (2018) Mouse lung fibroblasts are highly susceptible to necroptosis in a reactive oxygen species-dependent manner, Biochemical Pharmacology, 11 Jan 2018. * shared senior authorship

11. K. Habermann, L. Grünewald, S. J. L. van Wijk, S. Fulda (2017) Targeting redox homeostasis in rhabdomyosarcoma cells: GSH-depleting agents enhance auranofin-induced cell death, Cell Death and Disease, 8: 10.

10. S. J. L. van Wijk#, F. Fricke#, L. Herhaus, J. Gupta, K. Hötte, F. Pampaloni, P. Grumati, M. Kaulich, Y.S. Sou, M. Komatsu, F.R. Greten, S. Fulda, M. Heilemann, I. Dikic (2017) Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-kB and restricts bacterial proliferation, Nature Microbiology, 2: 17066. # shared first authorship

9. S. J. L. van Wijk, E. Fiskin, I. Dikic (2013) Selective monitoring of ubiquitin signals with genetically encoded ubiquitin chain-specific sensors, Nature Protocols, 8: 1449-58.

8. S. J. L. van Wijk, A. S. Melquiond, S. J. de Vries, H. Th. M. Timmers, A. M. Bonvin (2012) Dynamic control of selectivity in the ubiquitination pathway revealed by an ASP to GLU substitution in an intra-molecular salt-bridge network, PLOS Computational Biology, 8(11): e1002754.

7. S. J. L. van Wijk, E. Fiskin, M. Putyrski, F. Pampaloni, J. Hou, P. Wild, T. Kensche, H. E. Grecco, P. Bastiaens, I. Dikic (2012) Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells, Molecular Cell, 47: 797-809.

6. S. J. L. van Wijk, M. Bienko, I. Dikic (2012) Role of UbL family modifiers and their binding proteins in cell signaling. In R. J. Dohmen & M. Scheffner (Eds), Methods in Molecular Biology (163-71). Totowa, New Jersey, Humana Press. ISBN: 978-1-61779-473-5

5. F. Ikeda, Y. L. Deribe, S. S. Skånland, B. Stieglitz, C. Grabbe, M. Franz-Wachtel, S. J. L. van Wijk, P. Goswami, V. Nagy, J. Terzic, F. Tokunaga, A. Androulidaki, T. Nakagawa, M. Pasparakis, K. Iwai, J. P. Sundberg, L. Schaefer, K. Rittinger, B. Macek, I. Dikic (2011) SHARPIN forms a linear ubiquitin ligase complex regulating NF-kB activity and apoptosis, Nature, 471: 637-41.

4. S. J. L. van Wijk, S. Müller, I. Dikic (2011) Shared and unique properties of ubiquitin and SUMO networks in DNA repair, Genes & Development, 25(17):1763-9.

3. S. J. L. van Wijk, S. J. de Vries, P. Kemmeren, A. Huang, R. Boelens, A. M. J. J. Bonvin & H. Th. M. Timmers (2009) A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system, Molecular Systems Biology, 5: 295.

2. S. J. L. van Wijk, H. Th. M. Timmers (2009) The family of ubiquitin-conjugating enzymes (E2s): deciding between the life and death of proteins, FASEB Journal. 24: 981-93.

1. S. J. L. van Wijk, G. J. Hageman (2005) Poly (ADP-ribose) polymerase-1 mediated, caspase-independent cell death after ischemia/reperfusion, Free Radical Biology and Medicine, 39(1):81-90.