The major research interest of our lab is to understand how ubiquitination and (selective) autophagy control cell fate, e.g. the balance between cell survival and programmed forms of cell death, like apoptosis or necroptosis. Ubiquitination and autophagy are the two main cellular systems that control protein abundance, stability and function and both are controlled by complex enzymatic systems. Disturbances in ubiquitination or autophagy are associated with a plethora of human diseases, such as cancer, bacterial and viral infections and inflammation and therefore need to be tightly controlled.
The three main research themes of our lab are highlighted in further detail below: